Related Experiment Video
Updated: Aug 14, 2026
Production and Use of Lentivirus to Selectively Transduce Primary Oligodendrocyte Precursor Cells for In Vitro Myelination Assays
Published on: January 12, 2015
Physiologic properties of myelin proteins revealed by their expression in nonglial cells
D R Colman1, S M Staugaitis, D D'Urso
1Department of Anatomy and Cell Biology, Columbia University, College of Physicians & Surgeons, New York, New York 10032.
Abstract:
The transfection paradigm described herein can be used to investigate the functional properties of individual nervous system proteins in ways that have not been explored before. In particular, observations on the "structural" proteins of myelin are being made that have already yielded certain unique insights into the physiologic properties of these polypeptides. The ease with which site-directed mutagenesis procedures can be applied to these systems should eventually enable us to define with great precision the "functional domains" within each myelin protein.
