Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Runx2 and dental development.

Simon Camilleri1, Fraser McDonald

  • 1Department of Orthodontics, Dental Institute of Kings College London, London, UK. simon.camilleri@kcl.ac.uk

European Journal of Oral Sciences
|October 10, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: A probability model for estimating age in young individuals relative to key legal thresholds: 15, 18 or 21-year.

International journal of legal medicine·2024
Same author

A probability model for estimating age in young individuals relative to key legal thresholds: 15, 18 or 21-year.

International journal of legal medicine·2024
Same author

The effect of tooth borne versus skeletally anchored Alt-RAMEC protocol in early treatment of Class III malocclusion: a single-centre randomized clinical trial.

European journal of orthodontics·2023
Same author

Questions of logic in Atlas methods of dental age estimation.

Journal of forensic and legal medicine·2023
Same author

Root canal width as a mandibular maturity marker at the 18-year threshold in the Maltese population.

International journal of legal medicine·2022
Same author

Canine exposure: open or closed?

European journal of orthodontics·2021
Same journal

The emerging role of piRNAs in periodontal and orthodontic tissue dynamics: Biological insights and clinical perspectives-A review.

European journal of oral sciences·2026
Same journal

The speed of innovation versus the speed of validation: A growing governance gap in contemporary endodontics.

European journal of oral sciences·2026
Same journal

Effect of bioactive dentin modulators on adhesion of glass fiber posts.

European journal of oral sciences·2026
Same journal

Does the 2018 periodontal classification improve patient understanding? A missing piece in periodontal care.

European journal of oral sciences·2026
Same journal

Esthetic and adhesive properties of a novel colored fiber post: A restorative approach to an endodontic challenge.

European journal of oral sciences·2026
Same journal

Deep-layer integrity in bulk restorations: Effects of placement technique on fiber- and particulate-reinforced bulk-fill composites properties.

European journal of oral sciences·2026
See all related articles

The Runx2 gene is crucial for bone formation and tooth development. It regulates osteoblast lineage commitment, proliferation, and differentiation, and is vital for tooth calcification and eruption.

Area of Science:

  • Genetics
  • Developmental Biology
  • Biochemistry

Background:

  • Runx2 is a master transcription factor essential for bone formation.
  • It regulates osteoblast lineage commitment, proliferation, differentiation, and maintenance.
  • Runx2 also plays a critical role in tooth development and maintenance.

Purpose of the Study:

  • To describe the structure of the Runx2 gene.
  • To discuss the control and function of Runx2 in bone and tooth development.
  • To elucidate the role of Runx2 in the development of teeth and supporting structures.

Main Methods:

  • Literature review and analysis of existing research on Runx2.
  • Description of Runx2 gene structure and its regulatory mechanisms.
  • Discussion of Runx2's function in osteogenesis and odontogenesis.

Related Experiment Videos

Main Results:

  • Runx2 controls mesenchymal cell commitment to osteoblasts.
  • It influences proliferation, differentiation, and maintenance of osteoblasts.
  • Runx2 is essential for tooth calcification, eruption, and periodontal ligament maintenance.

Conclusions:

  • Runx2 is a key regulator in both bone and tooth development.
  • Its complex regulation ensures temporal and spatial control of its functions.
  • Understanding Runx2 is vital for comprehending craniofacial development and associated disorders.