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Selenium and cardiovascular disease.

O Oster1, W Prellwitz

  • 1Department of Clinical Chemistry, University Hospital Mainz, FRG.

Biological Trace Element Research
|February 1, 1990
PubMed
Summary
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Low selenium levels are linked to cardiovascular disease, including heart attacks and cardiomyopathy. Selenium deficiency may impair heart function and increase risks for hypertension and ischemia.

Area of Science:

  • Cardiovascular health
  • Nutritional science
  • Epidemiology

Background:

  • Ecological and epidemiological studies reveal a link between low serum selenium concentrations and cardiovascular disease in specific populations.
  • Clinical studies from Germany, Finland, and Sweden report subnormal selenium levels in patients with acute myocardial infarction.
  • Subnormal selenium concentrations are also observed in patients with coronary arteriosclerosis and cardiomyopathy in various countries.

Purpose of the Study:

  • To investigate the relationship between selenium concentration and cardiovascular disease.
  • To explore the mechanisms by which selenium deficiency may affect heart health.
  • To review evidence linking selenium status to conditions like myocardial infarction, coronary arteriosclerosis, and cardiomyopathy.

Main Methods:

Related Experiment Videos

  • Review of ecological and epidemiological data.
  • Analysis of clinical studies on patients with cardiovascular conditions.
  • Examination of animal experimental data on selenium's protective effects.

Main Results:

  • Low serum selenium concentrations are associated with cardiovascular disease in populations with selenium deficiency.
  • Patients with acute myocardial infarction, coronary arteriosclerosis, and cardiomyopathy often exhibit subnormal selenium levels.
  • Selenium deficiency can lead to lipid peroxide accumulation in the heart, potentially causing cell damage and impaired calcium transport.
  • Selenium deficiency may alter prostaglandin synthesis, increasing blood pressure and platelet aggregation.
  • Animal studies indicate selenium protects the heart from toxins and infections.

Conclusions:

  • Selenium deficiency is implicated in the development and progression of cardiovascular diseases.
  • Mechanisms include oxidative stress, impaired calcium handling, and altered prostaglandin synthesis.
  • Maintaining adequate selenium levels may be crucial for cardiovascular health and preventing conditions like hypertension and myocardial ischemia.