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Related Experiment Videos

Finasteride induced depression: a prospective study.

Babak Rahimi-Ardabili1, Ramin Pourandarjani, Peiman Habibollahi

  • 1Clinical Pharmacy Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ba.rahimi@gmail.com

BMC Clinical Pharmacology
|October 10, 2006
PubMed
Summary
This summary is machine-generated.

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Finasteride may increase depressive symptoms in men with androgenetic alopecia. This study found significant increases in depression scores after two months of finasteride treatment, suggesting cautious prescription for at-risk patients.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Dermatology

Background:

  • Finasteride inhibits 5 alpha-reductase, treating benign prostatic hyperplasia and androgenetic alopecia.
  • Animal studies and human case reports suggest finasteride may induce behavioral changes, including depression.
  • The link between finasteride and mood disorders requires further investigation.

Purpose of the Study:

  • To investigate the potential of finasteride to induce depressive symptoms and anxiety.
  • To assess mood changes in men with androgenetic alopecia undergoing finasteride treatment.

Main Methods:

  • 128 men with androgenetic alopecia were enrolled.
  • Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS) were used to assess mood.
  • Questionnaires were administered before treatment and two months post-treatment.

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Main Results:

  • Finasteride treatment significantly increased BDI scores (p < 0.001).
  • HADS depression scores also increased significantly (p = 0.005).
  • HADS anxiety scores showed a non-significant increase (p = 0.061).

Conclusions:

  • Finasteride may induce depressive symptoms, necessitating cautious prescribing in high-risk individuals.
  • Further research is needed to explore behavioral effects at higher doses and in susceptible populations.