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Updated: Jul 19, 2026
13:08
Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
Scleritis complicating zoledronic acid infusion.
David Benderson1, Joyson Karakunnel, Sajeev Kathuria
1Department of Ophthalmology, University of Maryland, Baltimore, MD 21201, USA.
Clinical Lymphoma & Myeloma
|October 10, 2006
Summary
Severe posterior scleritis, an eye inflammation, can occur after zoledronic acid treatment. Subsequent pamidronate use showed milder inflammation, suggesting potential immunologic tolerance to bisphosphonates.
Area of Science:
- Ophthalmology
- Rheumatology
- Pharmacology
Background:
- Bisphosphonates, including zoledronic acid and pamidronate, are commonly used to treat bone diseases.
- Posterior scleritis is a rare but serious ocular inflammation affecting the posterior part of the eye.
Observation:
- A case of severe unilateral posterior scleritis developed after zoledronic acid administration.
- The patient experienced milder inflammation in the same eye upon subsequent pamidronate treatment.
Findings:
- Timely recognition and treatment of zoledronic acid-induced posterior scleritis are crucial.
- Resolution of inflammation with continued pamidronate infusions suggests the development of immunologic tolerance.
Implications:
- Physicians should be aware of the potential for bisphosphonate-associated scleritis.
- Prompt diagnosis and management are essential to prevent potentially devastating visual outcomes.
- Further investigation into immunologic tolerance with bisphosphonates may be warranted.
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