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The relationship between rhinosinusitis and asthma sinusitis.

John W Steinke¹

¹Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908-1355, USA. js3ch@virginia.edu

Current Allergy and Asthma Reports

|October 10, 2006

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Chronic hyperplastic eosinophilic sinusitis (CHES) involves eosinophil proliferation and shares similarities with asthma. This review examines potential mechanisms linking these two inflammatory conditions, despite unproven temporal exacerbations.

Area of Science:

Immunology
Pulmonology
Otolaryngology

Background:

Chronic sinusitis encompasses inflammatory disorders with mucous gland hyperplasia and tissue remodeling.
Chronic hyperplastic eosinophilic sinusitis (CHES) is defined by excessive eosinophils, Th2 lymphocytes, fibroblasts, goblet cells, and mast cells.
CHES pathology resembles asthma, frequently co-occurring with it.

Purpose of the Study:

To explore the potential biological mechanisms connecting chronic hyperplastic eosinophilic sinusitis and asthma.
To investigate the relationship between CHES exacerbations and asthma worsening.

Main Methods:

Literature review of existing studies on CHES and asthma.
Examination of pathological similarities and potential shared inflammatory pathways.

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Analysis of reported temporal associations between CHES and asthma exacerbations.

Main Results:

CHES pathology shares key cellular and inflammatory features with asthma.
A frequent co-diagnosis of CHES and asthma suggests a potential link.
Reported temporal correlations between CHES exacerbations and asthma worsening exist but lack robust evidence.

Conclusions:

The similar pathology suggests a shared underlying inflammatory basis between CHES and asthma.
Further well-controlled studies are needed to confirm the proposed linkage and mechanisms.
Understanding these connections may improve management strategies for patients with both conditions.