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Updated: Jul 19, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Histological and biomechanical evaluation of implanted graft materials in a rabbit vaginal and abdominal model
Wesley S Hilger1, Andrew Walter, Mark E Zobitz
1Division of Gynecologic Surgery, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. hilger.wesley@mayo.edu
Objective:
The objective of the study was to describe the histologic and biomechanical changes of implanted dermal collagen graft materials.
Study Design:
Twenty rabbits were randomized into 2 groups (6 and 12 weeks, respectively). Each rabbit had 4 graft segments (human dermis, porcine dermis, porcine collagen-coated polypropylene mesh, and autologous fascia) randomly implanted into the abdomen and the vagina. Biomechanical testing and histologic analysis was performed after recovery of graft segments.
Results:
Dermal graft segments showed a marked decrease in ultimate strength (84% to 86%) and elastic modulus (73% to 82%) that was significantly different from the decrease seen in autologous fascia or coated synthetic mesh (P < .0008 and P < .0001, respectively). The decrease in ultimate strength was associated with vaginal implantation (P = .057). Dermal graft materials had moderate inflammation and minimal collagen infiltration.
Conclusion:
The mechanical properties of dermal graft materials decline after implantation. Vaginal implantation may cause a different tissue response to graft material than abdominal implantation. Dermal graft material caused moderate inflammation and minimal collagen ingrowth remote from implantation.
