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Relation between P-wave dispersion and left ventricular geometric patterns in newly diagnosed essential hypertension

Mustafa Gur1, Remzi Yilmaz, Recep Demirbag

  • 1Department of Cardiology, Faculty of Medicine, Harran University, Sanliurfa, Turkey. drmugur@yahoo.com

Journal of Electrocardiology
|October 10, 2006
PubMed

Insights

P-wave dispersion, a measure of atrial conduction, is elevated in hypertensive patients with left ventricular hypertrophy. This finding suggests P-wave dispersion is linked to left ventricular mass index, not just geometric patterns.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Hypertension Research

Background:

  • P-wave duration and dispersion (PD) indicate heterogeneous atrial conduction.
  • Hypertension can lead to significant changes in left ventricular (LV) geometry.

Purpose of the Study:

  • To investigate P-wave dispersion and P-wave duration in hypertensive patients with varying left ventricular geometric patterns.
  • To determine the relationship between PD and LV geometry in essential hypertension.

Main Methods:

  • 149 hypertensive patients and 29 controls underwent ECG and echocardiography.
  • P-wave durations (Pmax, Pmin) and PD were measured.
  • LV geometric patterns were classified based on LV mass index (LVMI) and relative wall thickness.

Main Results:

  • P-wave dispersion was significantly longer in concentric remodeling, concentric hypertrophy (CH), and eccentric hypertrophy (EH) compared to controls.
  • Patients with normal LV geometry had shorter PD than those with CH and EH.
  • PD was independently correlated with LVMI (beta = .425, P < .001) in multiple regression analysis.

Conclusions:

  • P-wave dispersion is independently associated with LVMI in hypertensive patients.
  • Elevated PD is particularly noted in hypertensive patients with CH and EH.
  • PD may serve as an indicator of altered atrial conduction in the context of hypertensive heart disease.
Abstract

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