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Related Experiment Videos

Flexible polyimide microelectrode array for in vivo recordings and current source density analysis.

Karen C Cheung1, Philippe Renaud, Heikki Tanila

  • 1University of British Columbia, Department of Electrical and Computer Engineering, Vancouver, Canada. kcheung@ece.ubc.ca

Biosensors & Bioelectronics
|October 10, 2006
PubMed
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Flexible polymer probes with microelectrodes enable effective neural recordings in rodents. These implantable devices show minimal tissue reaction and maintain signal quality for chronic in vivo studies.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Neural recording technologies are crucial for understanding brain function.
  • Existing silicon-based probes face limitations in flexibility and chronic implantation.
  • Development of biocompatible and durable neural probes is essential for long-term in vivo studies.

Purpose of the Study:

  • To present implantable, flexible polymer-based probes with embedded microelectrodes for neural recordings.
  • To evaluate the performance of these probes for both acute and chronic in vivo recordings in rodents.
  • To assess the biocompatibility and long-term stability of the polymer-based neural probes.

Main Methods:

  • Fabrication of flexible polymer-based probes with integrated microelectrodes.

Related Experiment Videos

  • Acute neural recordings in anesthetized mice, comparing polymer probes to silicon probes.
  • Chronic implantation of polymer probes in awake, behaving rats for up to 60 days.
  • Monitoring local field potentials, capturing laminar differences, and performing current source density analysis.
  • Histological and immunochemical analysis (GFAP staining) to assess tissue response.

    • Main Results:

    • Polymer-based probes yielded comparable results to silicon probes in acute recordings.
    • Chronic recordings in rats demonstrated stable signal amplitude and signal-to-noise ratios for 8 weeks.
    • The probes successfully monitored local field potentials and functional differences in the cortex and hippocampus.
    • Minimal tissue reaction, indicated by low glial fibrillary acidic protein expression, was observed 8 weeks post-implantation.
    • The probes could be utilized for lesion current application to mark tissue locations.

    Conclusions:

    • Flexible polymer-based probes are a viable alternative for acute and chronic neural recordings in vivo.
    • These probes offer excellent long-term stability and biocompatibility, with minimal inflammatory response.
    • The technology facilitates detailed electrophysiological studies of neural circuits in behaving animals.