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Updated: Jul 18, 2026

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
Published on: September 20, 2016
Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: identification of a lead and initial SAR studies
N Lambeng1, F Lebon, B Christophe
1CNS Molecular and Cellular Biology, Centre for CNS Innovation, UCB S.A., Chemin du Foriest, B-1420 Braine L'Alleud, Belgium.
Abstract:
High-throughput screening of the UCB sample collection identified the piperidinyl-sulfonyl benzoic ester 1 as a novel agonist for CB(1) receptor with nanomolar affinity. We report here the pharmacological profile of compound 1 as well as preliminary biological activities in pain model. Diverse close analogs of 1 were purchased and the structure-affinity relationships among this novel class are discussed.
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