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Related Experiment Videos

CLOCK leaves its mark on histones.

William J Belden1, Jennifer J Loros, Jay C Dunlap

  • 1Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA.

Trends in Biochemical Sciences
|October 10, 2006
PubMed
Summary
This summary is machine-generated.

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Mammalian circadian rhythms rely on a feedback loop involving CLOCK-BMAL1. Recent findings reveal CLOCK

Area of Science:

  • Molecular Biology
  • Genetics
  • Chronobiology

Background:

  • Circadian rhythms in mammals are regulated by a negative-feedback loop.
  • CLOCK-BMAL1 complex activates transcription of Period (PER) and Cryptochrome (CRY) genes.
  • PER and CRY proteins inhibit CLOCK-BMAL1 activity.

Purpose of the Study:

  • To investigate the role of chromatin remodeling in circadian rhythm transcriptional regulation.
  • To highlight the direct involvement of molecular clock components in chromatin modification.

Main Methods:

  • Review of recent reports on CLOCK protein activity.
  • Analysis of CLOCK's histone acetyltransferase (HAT) activity.

Main Results:

  • CLOCK possesses intrinsic histone acetyltransferase activity.

Related Experiment Videos

  • Molecular components of the biological clock can directly catalyze chromatin modifications.

    • Conclusions:

    • Chromatin remodeling is crucial for transcriptional regulation of circadian rhythm genes.
    • The CLOCK protein's HAT activity directly links the biological clock mechanism to chromatin modification.