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Asthma end points and outcomes: what have we learned?
Don Bukstein1, Monica Kraft, Andrew H Liu
1Allergy and Asthma Research, Dean Medical Center, Department of Pediatrics and Family Practice, University of Wisconsin Medical School, Madison, Wisconsin, USA.
The Journal of Allergy and Clinical Immunology
|October 10, 2006
Summary
Asthma diagnosis and treatment goals are not standardized, leading to poor outcomes. Measuring airway inflammation, like fraction of exhaled nitric oxide, may improve asthma control.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Clinical Medicine
Background:
- Asthma is prevalent with significant consequences, yet diagnosis and assessment lack standardization.
- Current asthma therapy goals are frequently unmet, highlighting a need for improved management strategies.
Purpose of the Study:
- To identify key asthma endpoints for guiding therapy.
- To evaluate strategies for standardizing asthma assessment and data analysis.
Main Methods:
- Comparative analysis of numerous clinical studies on asthma measures.
- Proposal for standardizing data collection and analysis in daily practice.
Main Results:
- Routine clinical measures like spirometric lung function do not consistently correlate with asthma control.
- Identifying measures that clearly reflect the disease process and are practical for office visits is crucial.
Conclusions:
- Standardized data analysis can define measures of true asthma control, likely addressing distal airway inflammation and hyperresponsiveness.
- Fraction of exhaled nitric oxide is proposed as a practical measure of inflammation for improved asthma evaluation and outcomes.
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