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Molecular and cellular basis of congenital heart disease

Tara L Sander1, Denise B Klinkner, Aoy Tomita-Mitchell

  • 1Department of Surgery, Division of Pediatric Surgery, Cardiovascular Research Center, Children's Research Institute and Medical College of Wisconsin, Children's Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. sandert@mcw.edu

Pediatric Clinics of North America
|October 10, 2006
PubMed

Insights

Understanding congenital heart disease (CHD) requires exploring cardiac development mechanisms. Further research is needed to define CHD causes and develop new prevention and therapy strategies.

Area of Science:

  • Cardiovascular biology
  • Developmental biology
  • Genetics

Background:

  • Congenital heart disease (CHD) research is rapidly advancing.
  • Understanding the cellular and molecular basis of CHD is crucial.

Purpose of the Study:

  • To introduce basic mechanisms of cardiac development and CHD.
  • To provide a foundation for understanding current and future diagnostics and therapeutics for CHD.

Main Methods:

  • Review of existing literature on cardiac development and CHD.
  • Analysis of current understanding of genetic and molecular pathways.

Main Results:

  • Significant progress has been made in understanding heart formation.
  • The direct causes of many congenital heart diseases remain poorly defined.

Conclusions:

  • Further studies are required to fully delineate the complexity of heart development mechanisms.
  • A comprehensive understanding of CHD etiologies will enable novel prevention and therapy development.

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