Related Experiment Video
Updated: Jul 19, 2026
Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
[Multiple gliomas: clinical studies and pathophysiological hypothesis]
K Auré1, F Laigle-Donadey, G Kaloshi
1Service de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Introduction:
Although a rare entity, multiple gliomas must be recognized and distinguished from other causes of multiple brain lesions.
Methods:
Clinical and radiological features of 33 multiple gliomas were reviewed, including 20 synchronous cases and 13 metachronous cases.
Results:
In 17 patients, radiological features were highly suggestive of spread from a primary site (multifocal gliomas). No apparent dissemination route was identified in the other cases which were presumed to be multicentric gliomas. For nine patients (27 percent), a second neoplasia or cancer was found in first degree relatives suggesting a genetic predisposition. Overall median survival was 79 weeks (64 weeks for glioblastomas). The age at onset was the main prognostic factor.
Conclusion:
Multiple gliomas represent a heterogeneous entity, probably corresponding to different mechanisms. In our group, survival was comparable to unique glioma.
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