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Updated: Jul 19, 2026

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
[Ischemic, an uncommon complication of Biermer disease (pernicious anemia)]
B Leemann1, N Boughanem, A Schnider
1Service de Rééducation, HUG, Switzerland. beatrice.leemann@hcuge.ch
Introduction:
Stroke in a young adult justifies an extensive etiologic workup.
Observation:
We present a 44-year-old women victim of a frontal ischemic stroke. Extensive evaluation was normal, except for high plasma level of homocysteine in the context of pernicious anemia, otherwise asymptomatic.
Discussion:
Hyperhomocysteinemia is a known marker, and probably risk factor for stroke, fostering atherosclerosis and thrombosis. It can be found among individuals suffering from homocystinuria, in individuals homozygous for the MHTFR T allele but also when there is deficiency of vitamin B12 or folic acid. Although it is very seldom ascribed, pernicious anemia would be a cause of stroke, possibly though hyperhomocysteinemia.
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