Related Experiment Video
Updated: Jul 19, 2026

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
Published on: July 21, 2023
Effects of interferon-gamma on bone remodeling during experimental tooth movement
Sila Mermut1, Ali Osman Bengi, Erol Akin
1Department of Orthodontics, Gulhane Military Medical Academy, Ankara, Turkey.
Objective:
To determine the effects of interferon-gamma (IFN-gamma) on bone remodeling during orthodontic tooth movement.
Materials And Methods:
Thirty adult male Sprague Dawley rats were randomly categorized into five groups. IFN-gamma was administered in three different doses (0.01, 0.02, and 0.05 microg/20 microL) and the remaining two groups served as control. Mandibular first molars were moved mesially by means of Ni-Ti closed coil springs in all groups. The results were evaluated histomorphometrically, and parameters of trabecular bone volume (BV/TV), trabecular bone number (Tr.N), and trabecular separation (Tr.Sep) were observed at the interradicular bone area of the mandibular first molars.
Results:
Increases in BV/TV and Tr.N and decreases in Tr.Sep revealed the antiosteoclastic activity of IFN-gamma.
Conclusion:
IFN-gamma administration may be useful clinically for anchorage control.
Related Concept Videos
Bone Remodeling
Bone Remodeling and Repair
Osteoclasts in Bone Remodeling

