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Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy
Published on: May 31, 2017
[Fulminant myocarditis presenting like acute myocardial infarction in a 6-year-old girl]
G Plat1, M-O Marcoux, R Bassil
1Service de Réanimation Pédiatrique Polyvalente, Hôpital des Enfants, 330, avenue de Grande-Bretagne, 31026 Toulouse, France.
Insights
Fulminant myocarditis is a rare, fatal pediatric heart condition. Early diagnosis and mechanical circulatory support are crucial but may not prevent sudden death in severe cases.
Area of Science:
- Pediatric Cardiology
- Critical Care Medicine
Background:
- Acute myocarditis presents a rare but severe inflammatory cardiac condition in children.
- Clinical manifestations range widely, from mild symptoms to life-threatening cardiovascular collapse.
Observation:
- A 6-year-old girl presented with electrocardiogram (ECG) abnormalities suggestive of myocardial infarction.
- The patient was diagnosed with fulminant myocarditis, a rapidly progressing form of the disease.
Findings:
- The child rapidly deteriorated, developing cardiogenic shock.
- Despite the potential for reversible cardiac function with circulatory support, the patient succumbed to the illness before mechanical support could be initiated.
Implications:
- This case highlights the critical and often rapid progression of fulminant myocarditis in pediatric patients.
- It underscores the urgent need for timely diagnosis and intervention strategies, including mechanical circulatory support, in managing this pediatric emergency.
Abstract:
Acute myocarditis is a rare inflammatory cardiac disease in children with potentially fatal issue. Clinical findings are very variable from nausea and vomiting to acute cardiovascular collapse. The cardiac function can be reversible with circulatory support. We report the case of a 6-year-old girl with ECG changes like myocardial infarction and diagnosis of fulminant myocarditis. She developped rapidly a cardiogenic shock and died before treatment with mechanical circulatory support.
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