Related Experiment Video
Updated: Jul 19, 2026
The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
Published on: July 8, 2015
Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor
Rita C Carvalho1, Camilla C Patti, André L Takatsu-Coleman
1Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, Brazil.
Abstract:
We investigated the effects of reserpine (0.1-0.5 mg/kg) on the performance of mice in the plus-maze discriminative avoidance task (DAVT), which simultaneously evaluates memory and motor activity. All doses induced memory impairment (increased aversive arm time) but only 0.5 mg/kg reserpine decreased locomotion (entries in enclosed arms). The results suggest that the DAVT evaluation in reserpine-treated mice can be a useful model for studying cognitive deficits accompanied by motor impairments.
