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Updated: Jul 19, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[Surgical management of cutaneous malignant melanoma. Review]
A Lavie1, C Desouches, D Casanova
1Service de chirurgie plastique et réparatrice, hôpital de La Conception, 147, boulevard baille, 13385 Marseille cedex 05, France. lavie@hotmail.com
Abstract:
Nowadays managing a cutaneous malignant melanoma can concern different kind of physicians: dermatologists, general or plastic surgeons The primary surgical procedure is a major step of the treatment. Biopsy must be total to properly determine the thickness of the tumor in case of malignancy. Wide local excision of the scar is often necessary to decrease the local and general recurrence rates. Wide local excision must be performed conforming to its own surgical rules. Managing tumor located on the face or limb extremities is a matter of plastic surgery. Sentinel node biopsy has succeeded to elective lymph node dissection. This procedure allows research of lymphatic spreading of the disease. Practice of sentinel node biopsy must be achieved in a protocolar way. Topography of the lesion can modified achievement and results of this procedure. Prognosis benefit of sentinel biopsy is now clear. Elective lymph node dissection is only performed in case of invaded sentinel node or clinically invaded lymph nodes. Local or locoregional recurrences mainly respond to surgical treatment using wide excision. However, alternative solutions are being evaluated (isolated limb perfusion).
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