Related Experiment Video
Updated: Jul 19, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Spectral, electrical conductivity and biological activity properties of some new azopyrimidine derivatives and their
Mamdouh S Masoud1, Ekram A Khalil, Ahmed M Ramadan
1Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt. drmsmasoud@yahoo.com
Abstract:
The electronic absorption spectra of 5-(o-substituted phenylazo)-6-amino-2-thiouracils and 6-(o-substituted phenylazo)-5-aminouracils containing different substituents are studied at different pH's. The dissociation constants are evaluated and discussed. Phenomenon of tautomerism is more supported by (1)H NMR and (13)C NMR spectra. The electrical conductivity of some ligands and their Co(II), Ni(II) and Cu(II) complexes in the temperature range 293-150K favoured their semiconducting properties where the metal ion forms a bridge to facilitate the flow of the current. The biological activity of some ligands and their complexes are tested against a number of Gram-positive and Gram-negative bacteria. The results showed that some of the compounds have a well considerable activity against some of the organisms.
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Physical Properties of Amines
Variables Affecting Phosphorescence and Fluorescence
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...

