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Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP

Sung B Lee1, Edward M Manno, Kennith F Layton

  • 1Division of Critical Care Neurology, Department of Neurology,Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

Neurology
|October 13, 2006
PubMed

To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin-associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.

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