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Updated: Jul 19, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
Published on: June 29, 2018
A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex
Anita K Roopun1, Steven J Middleton, Mark O Cunningham
1Medical School, University of Newcastle, Newcastle NE2 4HH, United Kingdom.
Abstract:
Beta2 frequency (20-30 Hz) oscillations appear over somatosensory and motor cortices in vivo during motor preparation and can be coherent with muscle electrical activity. We describe a beta2 frequency oscillation occurring in vitro in networks of layer V pyramidal cells, the cells of origin of the corticospinal tract. This beta2 oscillation depends on gap junctional coupling, but it survives a cut through layer 4 and, hence, does not depend on apical dendritic electrogenesis. It also survives a blockade of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors or a blockade of GABA(A) receptors that is sufficient to suppress gamma (30-70 Hz) oscillations in superficial cortical layers. The oscillation period is determined by the M type of K+ current.
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