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Thrombin/antithrombin III complex in patients with peripheral occlusive arterial disease
D Rość1, M Kotschy, M Rewakovicz
1Department of Pathophysiology, Medical Academy, Bydgoszcz, Poland.
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1990
Summary
Elevated thrombin/antithrombin III complex (TAT) levels were found in patients with peripheral obliterative arterial disease (POAD). This finding suggests TAT may indicate prethrombotic states, aiding clinical diagnosis.
Area of Science:
- Biochemistry
- Clinical Medicine
- Hematology
Background:
- Peripheral obliterative arterial disease (POAD) is a significant vascular condition.
- Hypercoagulability can be a precursor to thrombotic events.
- Accurate detection of prethrombotic states is crucial for patient management.
Purpose of the Study:
- To evaluate the utility of a new enzyme immunoassay (Enzygnost-TAT) for measuring thrombin/antithrombin III complex (TAT).
- To investigate the correlation between TAT levels and clinical parameters in patients with POAD.
Main Methods:
- Plasma samples from 36 patients with POAD and a control group were analyzed.
- The Enzygnost-TAT assay was used for quantitative determination of TAT levels.
- Statistical analysis was performed to correlate TAT levels with clinical factors.
Main Results:
- Patients with POAD exhibited elevated TAT levels compared to the control group.
- Increased TAT levels correlated with advanced atherosclerotic processes.
- Higher TAT levels were associated with comorbidities like hypertension and diabetes mellitus, and post-operative status.
Conclusions:
- The Enzygnost-TAT assay is a valuable tool for detecting prethrombotic states.
- Elevated TAT levels in POAD patients may indicate an increased risk of thrombosis.
- This assay can aid in the clinical diagnosis and management of hypercoagulable conditions.