Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute liver failure.

R J Fontana1, L G Quallich

  • 1Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. rfontana@umich.edu

Current Opinion in Gastroenterology
|October 13, 2006
PubMed
Summary

Acute liver failure (ALF) has diverse causes, including viral hepatitis and acetaminophen overdose. Emerging treatments like hypothermia and stem cell therapy show promise, but require further research and ethical consideration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The higher prevalence of truncal obesity and diabetes in American than Chinese patients with chronic hepatitis C might contribute to more rapid progression to advanced liver disease.

Alimentary pharmacology & therapeutics·2017
Same author

Good for the lung but bad for the liver? Garlic-induced hepatotoxicity following liver transplantation.

Journal of clinical pharmacy and therapeutics·2017
Same author

The Natural History of Severe Acute Liver Injury.

The American journal of gastroenterology·2017
Same author

Editorial: hepatocellular carcinoma--a rare complication of hepatic venous outflow tract obstruction.

Alimentary pharmacology & therapeutics·2015
Same author

Comparative analysis of portal hepatic infiltrating leucocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis.

Clinical and experimental immunology·2014
Same author

Changes in characteristics of hepatitis C patients seen in a liver centre in the United States during the last decade.

Journal of viral hepatitis·2014

Area of Science:

  • Hepatology
  • Toxicology
  • Regenerative Medicine

Background:

  • Viral hepatitis is a primary cause of acute liver failure globally.
  • Acetaminophen hepatotoxicity is the leading cause in Western countries.
  • Several medications have been withdrawn due to severe hepatotoxicity.

Purpose of the Study:

  • To review current understanding and emerging strategies for managing acute liver failure.
  • To highlight challenges and future directions in ALF treatment.

Main Methods:

  • Review of existing literature on ALF causes and treatments.
  • Discussion of novel therapeutic approaches including hypothermia, bioartificial liver support, transplantation, and stem cell therapy.

Main Results:

Related Experiment Videos

  • Acetaminophen overdose management strategies, such as restricting dispensed quantities, can reduce adverse outcomes.
  • Emerging treatments like moderate hypothermia show potential for reducing intracranial pressure.
  • Extracorporeal liver support devices and living donor liver transplantation are being explored.
  • Advances in identifying pluripotent liver stem cells offer hope for enhancing liver regeneration.

Conclusions:

  • Effective management of ALF requires addressing diverse etiologies and exploring innovative therapies.
  • Further clinical trials are essential to validate new treatments like hypothermia and bioartificial liver support.
  • Ethical considerations are paramount for advanced interventions like liver transplantation.
  • Stem cell research presents a promising avenue for improving native liver regeneration.