Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute pancreatitis.

C K Weber1, G Adler

  • 1Department of Internal Medicine I, University of Ulm, Ulm, Germany.

Current Opinion in Gastroenterology
|October 13, 2006
PubMed
Summary
This summary is machine-generated.

Understanding acute pancreatitis requires exploring acinar cell events, like trypsin activation. While research advances, translating these findings into effective human therapies and reliable prognostic markers remains a challenge.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IgG autoantibodies bound to surfaces of necrotic cells and complement C4 comprise the phagocytosis promoting activity for necrotic cells of systemic lupus erythaematosus sera.

Annals of the rheumatic diseases·2008
Same author

[CT colonography --"virtual colonoscopy"--a current review].

Zeitschrift fur Gastroenterologie·2004
Same author

Prediction of treatment response to rivastigmine in Alzheimer's dementia.

Journal of neurology, neurosurgery, and psychiatry·2004
Same author

[Dementias: communication between doctor, patient and relatives].

Deutsche medizinische Wochenschrift (1946)·2004
Same author

Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia.

Gut·2004
Same author

[Psychopharmacotherapy in advanced age].

Der Internist·2003
Same journal

Neuroendocrine tumors of the stomach and duodenum: evolving classification, endoscopic management, and surveillance.

Current opinion in gastroenterology·2026
Same journal

Endoscopic techniques to minimize gastroesophageal reflux during peroral endoscopic myotomy.

Current opinion in gastroenterology·2026
Same journal

Postendoscopy esophageal adenocarcinoma and neoplasia: current status and future directions.

Current opinion in gastroenterology·2026
Same journal

The complement system in inflammatory bowel disease: from early observations to emerging frontiers.

Current opinion in gastroenterology·2026
Same journal

Goblet cell-associated antigen passages in health and disease.

Current opinion in gastroenterology·2026
Same journal

Inflammatory bowel diseases 2026: form, function and therapeutic considerations for the epithelial barrier.

Current opinion in gastroenterology·2026
See all related articles

Area of Science:

  • Gastroenterology and Hepatology
  • Cell Biology
  • Immunology

Background:

  • Acute pancreatitis pathophysiology involves early acinar cell events, including trypsin activation.
  • Current understanding of experimental pancreatitis mechanisms lacks direct translation to human therapeutic strategies.
  • Predictive markers for individual acute pancreatitis patient outcomes are still undiscovered.

Purpose of the Study:

  • To investigate the cell biologic connections between intra-acinar protease activation and immunoregulatory processes in acute pancreatitis.
  • To explore the impact of these mechanisms on clinical management and prognostic marker identification.
  • To highlight the need for further research into pancreatic pathophysiology for novel therapeutic strategies.

Main Methods:

Related Experiment Videos

  • Review of existing literature on acute pancreatitis pathophysiology.
  • Analysis of molecular events in experimental pancreatitis models.
  • Correlation of cell biologic findings with clinical outcomes and patient management.

    • Main Results:

    • Early acinar cell events, such as trypsin activation, are central to acute pancreatitis.
    • The extent of the systemic inflammatory response is a critical factor in clinical outcomes.
    • Interconnectivity between protease activation and immune regulation influences disease progression.

    Conclusions:

    • Deciphering cell biologic pathways in pancreatitis impacts clinical management and prognostic marker identification.
    • Despite progress, effective human therapeutic strategies are not yet established.
    • Further investigation into pancreatic pathophysiology is crucial for developing novel treatments.