Related Experiment Video
Updated: Jul 19, 2026
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Safety of intravitreal injection of bevacizumab in rabbit eyes
Leonard Feiner1, Emily E Barr, Ying-Bo Shui
1Department of Ophthalmology and Visual Sciences/Campus Box 8096, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Purpose:
To evaluate the safety of intravitreal injection of bevacizumab in rabbits using electrophysiological testing and histopathologic analysis.
Methods:
New Zealand albino rabbits were injected in one eye with control antibody (n = 2), 0.05 mL of bevacizumab (n = 3), or 0.2 mL of bevacizumab (n = 3). Electroretinograms were obtained 1 week and 4 weeks after injection. Histologic analysis was performed after completion of the electroretinographic studies.
Results:
No statistical differences were seen in scotopic and photopic a- and b-wave amplitudes between untreated control and bevacizumab-injected eyes. No histopathologic differences were identified between untreated control and bevacizumab-injected eyes.
Conclusion:
Our study did not find evidence of retinal toxicity from a single intravitreal injection of bevacizumab in rabbits.
