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Updated: Jul 19, 2026
06:23
Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins
Published on: April 27, 2019
The role of SUMO in chromosome segregation
1Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, E Sussex, UK. f.z.watts@sussex.ac.uk
Chromosoma
|October 13, 2006
Summary
Small ubiquitin-like modifier (SUMO)ylation is crucial for accurate chromosome segregation during the eukaryotic cell cycle. This review highlights recent findings on SUMO
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- Chromosome segregation is vital for eukaryotic cell division.
- This process requires intricate coordination of cellular events.
- Potential regulatory roles of SUMOylation are increasingly recognized.
Purpose of the Study:
- To review recent findings on SUMOylation's role in chromosome segregation.
- To consolidate current understanding of SUMO's regulatory functions in this process.
Main Methods:
- Literature review of recent publications.
- Analysis of data on SUMO-modified targets.
- Synthesis of information on SUMO's involvement in key segregation processes.
Main Results:
- Emerging evidence points to critical roles for SUMOylation in regulating chromosome segregation.
- SUMOylation impacts multiple processes essential for accurate segregation.
- Identification of SUMO-modified targets provides insights into regulatory mechanisms.
Conclusions:
- SUMOylation is a key regulator of chromosome segregation.
- Further research into SUMOylation pathways will illuminate cell cycle control.
- Understanding SUMO's role is essential for comprehending eukaryotic cell division.
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