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Related Concept Videos

DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...

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Corrigendum: Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas.

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Related Experiment Video

Updated: Jul 19, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

p53 modulation of the DNA damage response.

E Scott Helton1, Xinbin Chen

  • 1Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Journal of Cellular Biochemistry
|October 13, 2006
PubMed
Summary

The tumor suppressor p53 is crucial for DNA damage response, promoting survival initially but triggering cell elimination when damage is severe. This review explores its dual roles in regulating cell fate after genotoxic stress.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • The tumor suppressor p53 is a key regulator in cellular responses to DNA damage.
  • p53 influences cell fate decisions, balancing survival and elimination pathways.
  • Genotoxic stress activates p53, initiating complex regulatory mechanisms.

Purpose of the Study:

  • To review the transcriptional-dependent and -independent functions of p53.
  • To elucidate the dual role of p53 in regulating cell fate following DNA damage.
  • To provide a comprehensive overview of p53's involvement in the DNA damage response.

Main Methods:

  • Literature review of studies on p53 and DNA damage response.
  • Analysis of transcriptional and non-transcriptional mechanisms of p53.

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Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
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Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

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Last Updated: Jul 19, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
04:56

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

  • Synthesis of findings on p53's role in cell cycle arrest, DNA repair, and apoptosis.

    • Main Results:

    • p53 initially promotes cell survival through pro-survival pathways like cell cycle arrest and DNA repair.
    • p53 can induce elimination of cells with extensive DNA damage or aberrant growth.
    • Both transcriptional and non-transcriptional activities of p53 are vital for its function.

    Conclusions:

    • p53 acts as a critical checkpoint, determining cell fate after genotoxic stress.
    • Understanding p53's multifaceted roles is essential for comprehending DNA damage response.
    • Further research into p53's mechanisms can inform therapeutic strategies for cancer and other diseases.