Related Experiment Video
Updated: Jul 6, 2026

Molecular Evolution of the Tre Recombinase
Published on: May 29, 2008
Ligand-controlled, complementary stereoselectivity in the platinum-catalyzed intramolecular silaboration of alkenes
Toshimichi Ohmura1, Hideki Furukawa, Michinori Suginome
1Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan.
Abstract:
An intramolecular silaboration of borylsilanyl homoallyl ethers was achieved using a platinum catalyst, giving 1-oxa-2-silacyclopentanes in high yields. The stereoselectivity of the reactions of sec-homoallyl ethers strongly depended on the phosphorus ligand of the platinum catalysts used. The platinum complex bearing the PCyPh2 ligand was found to be the most trans-selective catalyst (trans/cis = 81:19-92:8), whereas a highly cis-selective cyclization was achieved using a platinum catalyst having tris(2,4-di-tert-butylphenyl)phosphite ligand (trans/cis = 8:92-6:94). The synthetic utility of the intramolecular silaboration was demonstrated by the complementary synthesis of a pair of diastereomers of 6-methylheptane-1,3,5-triol.
Related Concept Videos
Protein Complexes with Interchangeable Parts
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Gene Conversion
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Combinatorial Gene Control
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Gene Conversion

