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Related Experiment Video

Updated: Jul 19, 2026

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats

Published on: May 27, 2021

New treatments for tic disorders.

Mohammad M Qasaymeh¹, Jonathan W Mink

¹Child Neurology, Box 631, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA. jonathan_mink@urmc.rochester.edu.

Current Treatment Options in Neurology

|October 13, 2006

Summary

Treatment for tic disorders ranges from education for mild cases to medications like clonidine or guanfacine for moderate severity. Severe tics may require dopamine receptor blockers, with atypical neuroleptics preferred over standard ones.

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Area of Science:

Neurology
Psychiatry

Background:

Tic disorders present a spectrum of severity, impacting daily life to varying degrees.
Comorbid conditions, such as ADHD and OCD, affect over 50% of patients and can be more debilitating than tics themselves.

Purpose of the Study:

To outline treatment strategies for tic disorders based on symptom severity and patient impact.
To review first-line and advanced pharmacological interventions for tics.

Main Methods:

Review of current treatment guidelines and emerging research for tic disorder management.
Discussion of medication classes including alpha-adrenergic agonists and dopamine receptor blockers.
Consideration of behavioral therapy as a treatment option.

Main Results:

Mild tics may only require education and reassurance.
Clonidine and guanfacine are recommended first-line medications for moderate tics due to their safety profile.
Atypical neuroleptics like risperidone are preferred over standard antipsychotics for severe tics due to a better side effect profile.

Conclusions:

Treatment should be individualized to the most bothersome symptoms.
Pharmacological interventions range from alpha-adrenergic agonists to dopamine receptor blockers, with careful consideration of side effects.
Behavioral therapies show promise and should be considered in treatment plans.