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Updated: Jul 19, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
Continuous peripheral nerve block in combat casualties receiving low-molecular weight heparin
C C Buckenmaier1, C H Shields, A A Auton
1Army Regional Anesthesia and Pain Management Initiative, Anesthesia and Operative Service, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA. chester.buckenmaier@na.amedd.army.mil
Continuous peripheral nerve blocks (CPNB) in combat trauma patients receiving low-molecular weight heparin (LMWH) showed no catheter-related bleeding. This study introduces institutional guidelines for managing CPNB catheters during LMWH therapy.
Area of Science:
- Anesthesiology
- Pain Management
- Trauma Surgery
Background:
- Continuous peripheral nerve block (CPNB) is vital for managing pain in combat casualties.
- Concurrent use of low-molecular weight heparin (LMWH) for venous thromboembolism prevention requires careful management of CPNB.
- Limited data exists on the safety of CPNB in patients receiving LMWH.
Purpose of the Study:
- To describe the experience of using CPNB in combat trauma patients treated with LMWH.
- To introduce institutional guidelines for managing CPNB catheters in patients on LMWH.
- To evaluate the safety and complication rates of CPNB in this patient population.
Main Methods:
- Retrospective chart review of 187 combat casualties treated with CPNB from March 2003 to April 2005.
- Data collected included CPNB type, duration, LMWH indication and dosage, and timing of LMWH administration relative to catheter placement/removal.
- Complications related to CPNB and bleeding events were recorded.
Main Results:
- Median LMWH (enoxaparin) dose was 30 mg given 21 hours before catheter insertion and 12 hours after removal.
- Catheters remained in place for a median of 8 days.
- Catheter-specific complications occurred in 3.7% of patients, with no catheter-related bleeding events observed.
Conclusions:
- Concurrent use of CPNB and LMWH in combat trauma patients appears safe, with no catheter-related bleeding complications in this series.
- Institutional guidelines can facilitate safe management of CPNB in patients receiving LMWH.
- Further research is warranted to confirm safety and optimize management strategies.
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