Related Experiment Video

Updated: Jul 19, 2026

Measuring Liver Mitochondrial Oxygen Consumption and Proton Leak Kinetics to Estimate Mitochondrial Respiration in Holstein Dairy Cattle

Measuring Liver Mitochondrial Oxygen Consumption and Proton Leak Kinetics to Estimate Mitochondrial Respiration in Holstein Dairy Cattle

Published on: November 30, 2018

Effect of manganese source on manganese absorption by the intestine of broilers

F Ji¹, X G Luo, L Lu

¹Mineral Nutrition Research Division, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, China.

Poultry Science

|October 13, 2006

Abstract:

Two experiments were conducted to investigate the effect of Mn source on Mn absorption by the intestine of broilers. In Experiment 1, the effect of Mn source, including MnSO(4), 2 Mn-amino acid chelates (Mn-Gly and Mn-Met) synthesized in our laboratory, 3 Mn-amino acid complexes with different complex strengths (Mn-Met E, Mn-AA A, and Mn-AA B), and 2 mixtures of MnSO(4) with Gly or Met, on Mn absorption was assessed with ligated loops of different small intestinal segments of broilers. In Experiment 2, the absorption of Mn from MnSO(4), Mn-AA A, and Mn-AA B was compared with intact broilers fed ad libitum. The criterion used for comparison was the Mn content of hepatic portal vein plasma. The absorption of Mn was higher (P < 0.0002) by ligated ileal loops than by duodenal and jejunal ones. Met supplementation increased (P < 0.03) the absorption of Mn as MnSO(4). The absorption of Mn as Mn-AA A and Mn-AA B with moderate and strong complex strengths, respectively, were higher (P < 0.05) than those of Mn as MnSO(4) and Mn-Met E with weak complex strength. On d 7 and 9 of Experiment 2, the Mn content of portal vein plasma was higher (P < 0.03) for Mn-AA B with strong complex strength than for MnSO(4). On d 9, Mn content in plasma was higher (P < 0.01) for Mn-AA B with strong complex strength than for Mn-AA A with a moderate one. The results from this study confirm that the ileum was the main site of Mn absorption for broilers, and Met was more effective in facilitating Mn absorption than Gly as a ligand. Organic Mn was more efficiently absorbed than inorganic Mn (MnSO(4)); the absorption of organic Mn with moderate and strong complex strengths was greater than that of the organic Mn, which was weak, and the absorption of organic Mn with strong complex strength was greater than that of the organic Mn with a moderate strength.

Insights

The ileum is the primary site for manganese (Mn) absorption in broilers. Organic Mn sources, particularly those with strong complex strengths, are absorbed more efficiently than inorganic manganese sulfate.

Area of Science:

Animal Nutrition
Poultry Science
Mineral Metabolism

Background:

Manganese (Mn) is an essential trace element for broiler growth and health.
Understanding Mn absorption is crucial for optimizing poultry diets and preventing deficiencies.
Different Mn sources vary in their bioavailability and absorption efficiency.

Purpose of the Study:

To investigate the effect of different manganese (Mn) sources on Mn absorption in broilers.
To compare the absorption of inorganic Mn (MnSO(4)) with various organic Mn forms (chelates and complexes).
To identify the primary site of Mn absorption within the broiler small intestine.

Main Methods:

Experiment 1: Utilized ligated intestinal loops (duodenum, jejunum, ileum) in broilers to assess Mn absorption from MnSO(4), Mn-amino acid chelates, Mn-amino acid complexes with varying strengths, and MnSO(4) mixtures.
Experiment 2: Compared Mn absorption from MnSO(4), Mn-amino acid complex A (moderate strength), and Mn-amino acid complex B (strong strength) in intact, ad libitum-fed broilers.
Measured Mn content in hepatic portal vein plasma as the primary indicator of absorption.

Main Results:

The ileum was identified as the main site for Mn absorption in broilers.
Organic Mn sources, especially those with moderate (Mn-AA A) and strong (Mn-AA B) complex strengths, showed significantly higher absorption than inorganic MnSO(4).
Methionine (Met) supplementation enhanced MnSO(4) absorption, and organic Mn with strong complex strength was absorbed more efficiently than that with moderate strength.

Conclusions:

Organic manganese forms are superior to inorganic manganese sulfate for broiler absorption.
The complex strength of organic Mn significantly influences its absorption efficiency, with stronger complexes being more bioavailable.
Methionine acts as an effective ligand, enhancing manganese absorption.

Read full analysis

More Related Videos

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth

Published on: September 20, 2021

Related Concept Videos

Microbes and Other Elemental Cycles

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...

Bioavailability: Influencing Factors

Bioavailability: Influencing Factors

Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...

Articles linked to this work by shared authors, journal, and citation graph.

Plasmid DNAs encoding insulin and glutamic acid decarboxylase 65 have distinct effects on the progression of autoimmune diabetes in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)·2001

[Study of the cytotoxity against human hepatocellular carcinoma cells induced by the MAGE-1 gene modified dendritic cells].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2001

Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration.

American journal of physiology. Heart and circulatory physiology·2001

Anodic cyclization reactions: reversing the polarity of ketene dithioacetal groups.

Organic letters·2001

Assessment of total energy expenditure in a Chinese population by a physical activity questionnaire: examination of validity.

International journal of food sciences and nutrition·2001

Downregulation of the ERK 1 and 2 mitogen activated protein kinases using antisense oligonucleotides inhibits proliferation of porcine vascular smooth muscle cells.

Atherosclerosis·2001

See all related articles