Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Portal hypertension.

Guadalupe Garcia-Tsao1

  • 1Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06520, USA. guadalupe.garcia-tsao@yale.edu

Current Opinion in Gastroenterology
|October 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-absorbable antibiotics worsen alcohol-associated liver disease in gastric acid-suppressed mice.

Gut microbes·2026
Same author

Frailty Increases Hospitalization Rates in an Ambulatory Cohort of Patients With Cirrhosis: The North American Consortium for the Study of End-Stage Liver Disease 3 Prospective Cohort.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Cirrhosis, portal hypertension and hepatocellular carcinoma: a stage-based approach.

Nature reviews. Gastroenterology & hepatology·2026
Same author

Variceal hemorrhage in cirrhosis.

Expert review of gastroenterology & hepatology·2026
Same author

The management of hepatorenal syndrome-acute kidney injury (HRS-AKI): A national survey of hepatology provider practices.

Hepatology communications·2026
Same author

Biomarkers of inflammation and risk of adverse events in patients with cirrhosis.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026

Portal hypertension, a complication of cirrhosis, causes serious issues like bleeding varices and ascites. Understanding its hemodynamic effects is key to managing these severe liver disease complications.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Portal hypertension is the primary complication of cirrhosis.
  • It leads to severe conditions including variceal hemorrhage, ascites, and hepatic encephalopathy.
  • Hemodynamic changes like splanchnic vasodilatation and hyperdynamic circulation are characteristic of portal hypertension.

Purpose of the Study:

  • To elucidate the mechanisms and consequences of portal hypertension in cirrhosis.
  • To explain the pathophysiology of major complications associated with portal hypertension.

Main Methods:

  • Review of existing literature on cirrhosis and portal hypertension.
  • Analysis of hemodynamic alterations in cirrhotic patients.
  • Explanation of the pathogenesis of key complications.

Related Experiment Videos

Main Results:

  • Portal hypertension stems from increased intrahepatic resistance and portal venous inflow.
  • Complications arise from sinusoidal hypertension, vasodilatation, and neurohumoral activation.
  • Specific conditions like ascites, hepatic hydrothorax, hepatorenal syndrome, SBP, and encephalopathy are direct or indirect results.

Conclusions:

  • Portal hypertension drives the major complications of cirrhosis.
  • Understanding these pathophysiological pathways is crucial for effective clinical management.
  • Targeting hemodynamic abnormalities may offer therapeutic strategies for cirrhotic complications.