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Updated: Jul 19, 2026
09:54
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
Immunizations during HIV infection
1Community Research Initiative on AIDS, New York, NY 10001, USA.
Current Opinion in Infectious Diseases
|October 13, 2006
Summary
Immunizing persons with human immunodeficiency virus (HIV) for other diseases is safe and effective. While some studies show temporary increases in HIV viral load, these are unlikely to cause harm, especially with modern antiretroviral therapy.
Area of Science:
- Immunology
- Infectious Diseases
- Vaccinology
Background:
- The safety and efficacy of vaccines in individuals with human immunodeficiency virus (HIV) have been debated.
- Concerns exist regarding potential transient increases in HIV viral load post-immunization.
Purpose of the Study:
- To evaluate the safety and clinical efficacy of immunizing HIV-infected individuals against other diseases.
Main Methods:
- Review of existing studies on immunization in HIV-infected populations.
- Analysis of reported changes in HIV viral load and serological responses.
Main Results:
- Transient increases in HIV viral load were observed in some studies but are generally not clinically significant, particularly with effective antiretroviral therapy.
- Despite a reduced serological response in HIV-infected individuals, immunization demonstrates some clinical efficacy.
Conclusions:
- Immunization of HIV-infected individuals is considered safe and offers clinical benefits.
- The benefits of vaccination outweigh the minimal risks of transient viral load increase in the context of current HIV treatment regimens.
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