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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...

Staphylococcal Skin Infections

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

Cryptococcal Meningitis

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

Candidiasis

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

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Updated: Jul 19, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Dermatological infections in the immunocompromised host.

¹Institut de Recherche sur la Peau et Service de Dermatologie 1, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France. h.bachelez@chu-stlouis.fr

Current Opinion in Infectious Diseases

|October 13, 2006

Summary

Human herpes virus 8 is linked to Kaposi

Area of Science:

Virology and Oncology
Infectious Diseases

Background:

Recent studies increasingly support a pathogenic role for human herpes virus 8 (HHV-8) in Kaposi's sarcoma.
Emerging research explores HHV-8 sensitivity to antiviral therapies.
This review encompasses diverse infectious disease topics, including atypical bacterial/mycobacterial presentations and specific viral/bacterial infections in immunocompromised populations.

Purpose of the Study:

To review current evidence linking human herpes virus 8 to Kaposi's sarcoma pathogenesis.
To summarize initial findings on human herpes virus 8 antiviral drug sensitivity.
To discuss significant findings in varicella zoster virus prevention and early syphilis treatment in HIV patients.

Main Methods:

Literature review of recent studies on human herpes virus 8.

Related Experiment Videos

Last Updated: Jul 19, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Analysis of early research on human herpes virus 8 antiviral drug sensitivity.

Inclusion of data from trials on varicella zoster virus vaccination and HIV-associated syphilis treatment.

Main Results:

Strong evidence supports human herpes virus 8's role in Kaposi's sarcoma tumoral hyperplasia.
First results on human herpes virus 8 antiviral drug sensitivity are now available.
Key trials highlight varicella zoster virus prevention strategies and effective early syphilis management in HIV patients.

Conclusions:

Human herpes virus 8 is a significant factor in Kaposi's sarcoma development.
Antiviral drug efficacy against human herpes virus 8 requires further investigation.
Comprehensive management of opportunistic infections is crucial in immunocompromised individuals.