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Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
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Morphogenesis of the polaroplast in Enterocytozoon bieneusi Desportes et al., 1985, a microsporidan parasite of HIV infected patients.

European journal of protistology·2012
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Evaluation of an immunofluorescent-antibody test using monoclonal antibodies directed against Enterocytozoon bieneusi and Encephalitozoon intestinalis for diagnosis of intestinal microsporidiosis in Bamako (Mali).

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Monoclonal antibody enabling the diagnosis of Encephalitozoon intestinalis in fecal specimens: importance of the mode of selection of hybridomas.

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An ELISA test to detect human serum antibodies reactive with Encephalitozoon intestinalis.

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In vitro activity of antimitotic compounds against the microsporidium Encephalitozoon intestinalis.

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Updated: Jul 19, 2026

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection
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Human microsporidioses.

I Desportes-Livage1

  • 1Unité INSERM 313, CHU Pitié-Salpêtrière, 91 boulevard de l'Hôpital, 75013, Paris, France.

Current Opinion in Infectious Diseases
|October 13, 2006
PubMed
Summary

Molecular techniques advance microsporidiosis research, revealing infections in diverse patients. Fumagillin shows potential efficacy, and antiretroviral therapy aids remission in HIV patients.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Parasitology

Background:

  • Microsporidiosis research is evolving with new molecular techniques.
  • Severe disseminated microsporidiosis affects AIDS patients, but also HIV-seronegative individuals.
  • Understanding microsporidiosis in immunocompetent hosts is increasingly important.

Purpose of the Study:

  • To review recent advancements in microsporidiosis research.
  • To highlight the application of molecular methods in studying microsporidiosis.
  • To discuss the clinical spectrum and treatment of microsporidiosis.

Main Methods:

  • Utilizing molecular techniques for clinical specimen analysis.
  • Conducting epidemiological and phylogenetic studies.

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  • Reviewing literature on severe disseminated and opportunistic microsporidiosis.

    • Main Results:

    • Molecular methods are increasingly used for diagnosis and research.
    • Microsporidiosis is observed in both AIDS patients and immunocompetent individuals.
    • Fumagillin demonstrates potential efficacy against Enterocytozoon bieneusi infections.
    • Antiretroviral therapy can lead to remission of intestinal microsporidiosis in HIV-infected patients.

    Conclusions:

    • Molecular techniques are crucial for advancing microsporidiosis research.
    • The clinical presentation of microsporidiosis is expanding beyond AIDS patients.
    • Fumagillin and antiretroviral therapy represent key therapeutic avenues.