Related Experiment Video
Updated: Jul 19, 2026
11:36
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Imatinib mesylate-induced acute hepatitis with autoimmune features
Valérie Dhalluin-Venier1, Caroline Besson, Stéphanie Dimet
1Hepatogastroenterology, Bicêtre Hospital, LeKremlin Bicêtre, France. Valerie.dhalluin@bct.ap-hop-paris.fr
European Journal of Gastroenterology & Hepatology
|October 13, 2006
Summary
Imatinib mesylate, an anticancer drug, can cause autoimmune hepatitis. This is the first reported case of drug-induced hepatitis with autoimmune features linked to imatinib.
Area of Science:
- Hepatology
- Oncology
- Immunology
Background:
- Autoimmune hepatitis (AIH) is an idiopathic liver disease.
- Imatinib is a targeted anticancer agent for chronic myeloid leukemia and gastrointestinal tumors.
Observation:
- A patient developed hepatitis with autoimmune features.
Findings:
- The hepatitis was associated with imatinib mesylate treatment.
- This represents the first documented instance of imatinib mesylate-induced hepatitis exhibiting autoimmune characteristics.
Implications:
- This finding expands the known adverse effects of imatinib.
- Clinicians should consider imatinib as a potential cause of autoimmune-like hepatitis.
- Further research is needed to understand the mechanism of imatinib-induced autoimmune hepatitis.
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