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Related Experiment Videos

[Hyperthermia as a method for treating prostatic adenoma].

M F Trapeznikova, G V Goldobenko, V A Odinokova

    Urologiia I Nefrologiia
    |July 1, 1990
    PubMed
    Summary

    Microwave hyperthermia offers a safe, conservative treatment for prostatic adenoma in older men. This therapy reduced prostate size and improved urinary flow, though some patients still required surgery.

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    Area of Science:

    • Urology
    • Oncology
    • Medical Physics

    Background:

    • Prostatic adenoma, a common condition in aging men, can cause severe lower urinary tract symptoms.
    • Traditional treatments may carry risks or be unsuitable for all patients, particularly those with contraindications for surgery.
    • Microwave hyperthermia presents a potential non-invasive therapeutic option for managing benign prostatic hyperplasia (BPH).

    Purpose of the Study:

    • To evaluate the efficacy and safety of local microwave hyperthermia as a treatment for symptomatic prostatic adenoma.
    • To assess the impact of hyperthermia on prostate size, urinary flow, and residual urine volume.
    • To determine the potential for microwave hyperthermia as a conservative management strategy for inoperable patients.

    Main Methods:

    • Fifteen male patients (60-76 years) with severe prostatic adenoma symptoms received six local microwave hyperthermia treatments (41-42°C) using 915 or 460 MHz devices.
    • Treatments were administered twice weekly with 3-4 day intervals to prevent thermic tolerance.
    • Patients with urinary or prostatic stones were excluded; those with severe symptoms were included.

    Main Results:

    • Prostate size decreased by an average of 15.2 cm² in 11 out of 15 patients.
    • The treatment was well-tolerated, leading to improved uroflowmetric findings and abolition of residual urine in most patients.
    • Focal sclerosis was induced in the adenoma tissue; however, three patients required surgery for adenoma distension and three for cystostomies post-treatment.

    Conclusions:

    • Local microwave hyperthermia demonstrates potential as a safe and effective conservative treatment for prostatic adenoma, particularly in inoperable patients.
    • The therapy can lead to significant prostate volume reduction and symptomatic improvement, including better urinary flow and reduced residual urine.
    • While generally safe, careful patient selection is necessary, as some individuals may still require surgical intervention.

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