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Published on: August 20, 2014
Surface and hemocompatibility studies of bi-soft segment polyurethane membranes
D P Queiroz1, I M Pinto, M C F Besteiro
1Department of Chemical Engineering, Higher Institute of Technology, Lisbon - Portugal.
The International Journal of Artificial Organs
|October 13, 2006
Summary
Adding polybutadiene diol (PBDO) to polyurethane/urea (PUR) membranes improved hemocompatibility, reducing blood clotting and hemolysis. The 10% PBDO membrane showed the best performance, offering non-hemolytic and low thrombogenic properties.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Science
Background:
- Polyurethane/urea (PUR) membranes are used in biomedical applications.
- Modifying membrane composition can enhance hemocompatibility.
- Understanding surface properties is crucial for blood-contacting materials.
Purpose of the Study:
- To evaluate the surface energy and hemocompatibility of cross-linked PUR/PBDO membranes.
- To investigate the effect of varying polybutadiene diol (PBDO) content on membrane properties.
- To determine the optimal PBDO concentration for improved hemocompatibility.
Main Methods:
- Preparation of cross-linked PUR/PBDO membranes with varying compositions.
- Measurement of membrane surface energy.
- Assessment of hemocompatibility, including hemolysis and thrombosis assays.
- Evaluation of blood-material contact time effects on thrombogenicity.
Main Results:
- Membrane surface energy increased with PBDO content up to 25%, then decreased.
- Introduction of PBDO rendered hemolytic membranes non-hemolytic.
- Thrombogenicity significantly decreased with PBDO addition, especially at 10% PBDO.
- Hemolysis degree showed no significant variation with PBDO content.
- Thrombogenicity increased with PBDO content above 10% for 10-minute blood contact.
- All tested membranes were less thrombogenic than glass at 10-minute blood contact.
Conclusions:
- Cross-linked PUR/PBDO membranes exhibit tunable surface energy and improved hemocompatibility.
- PBDO incorporation effectively reduces blood-material interactions, making membranes non-hemolytic and less thrombogenic.
- The 10% PBDO membrane demonstrates optimal hemocompatibility, suggesting its potential for biomedical applications.
