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Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes

Peter H Sugden1, Angela Clerk

  • 1National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London, United Kingdom. p.sugden@imperial.ac.uk

Antioxidants & Redox Signaling
|October 13, 2006
PubMed

Insights

Reactive oxygen species (ROS) contribute to cardiac myocyte growth, acting as signaling molecules. These findings highlight ROS

Area of Science:

  • Cardiovascular Biology
  • Cell Signaling
  • Oxidative Stress Research

Background:

  • Oxidative stress is known for its toxic cellular effects.
  • Emerging evidence indicates reactive oxygen species (ROS) promote cardiac myocyte growth.
  • ROS may function as endogenous 'second messenger' molecules in cellular signaling.

Purpose of the Study:

  • To review intracellular signaling pathways activated by ROS in cardiac myocytes.
  • To explore the mechanisms by which ROS activate these growth-promoting pathways.
  • To discuss the role of ROS in mediating the effects of neurohumoral agonists.

Main Methods:

  • Literature review of studies on ROS and cardiac myocyte signaling.
  • Analysis of established and proposed mechanisms of ROS-induced pathway activation.
  • Discussion of key signaling molecules including MAPK cascades and PI3K/Akt pathway.

Main Results:

  • ROS activate major growth-promoting signaling pathways in cardiac myocytes.
  • Key pathways include mitogen-activated protein kinase (MAPK) cascades and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt).
  • Mechanisms involve direct oxidation of phosphatases, involvement of kinases like PKC and ASK1, and Ras activation.

Conclusions:

  • Reactive oxygen species (ROS) play a significant role in promoting cardiac myocyte growth.
  • ROS activate critical intracellular signaling pathways, including MAPK and PI3K/Akt.
  • Understanding these ROS-mediated pathways is crucial for cardiovascular research and therapeutics.

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