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Updated: Jul 19, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste
Terence S C Poon1, Susanne Freeman
1Skin and Cancer Foundation, Sydney, New South Wales, Australia.
Abstract:
A 63-year-old woman presented with a 6-year history of persistent cheilitis. Minimal improvement was achieved with therapeutic measures. Patch testing was positive to anethole, a flavouring used in her toothpaste. Her cheilitis resolved after cessation of the flavoured toothpaste. This case demonstrates the importance of considering contact allergy to toothpaste flavours in patients with cheilitis.
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