Related Experiment Video
Updated: Jul 19, 2026

Culture of Adult Transgenic Zebrafish Retinal Explants for Live-cell Imaging by Multiphoton Microscopy
Published on: February 24, 2017
Cellular pattern formation during retinal regeneration: a role for homotypic control of cell fate acquisition
Melinda J Tyler1, David A Cameron
1Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY 13210, USA.
Abstract:
A dominant mechanism of cellular patterning in the growing fish retina is control of cell fate acquisition by negative feedback signals arising from differentiated cells. We tested the ability of a computational model of this pattern formation mechanism to simulate cellular patterns in regenerated goldfish retina. The model successfully simulated quantitative features of in vivo regenerated patterns, indicating that regenerating retina has access to and utilizes patterning mechanisms that are operational during normal growth. The atypical patterns of regenerated retina could arise in part from regenerative progenitors that, compared to normal growth progenitors, are less responsive to the feedback patterning signals.
More Related Videos
09:47Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
Published on: December 9, 2022
10:36In Vivo Imaging of Transgenic Gene Expression in Individual Retinal Progenitors in Chimeric Zebrafish Embryos to Study Cell Nonautonomous Influences
Published on: March 22, 2017
Related Concept Videos
Cellular Differentiation
A zygote is a...
Cell Migration
Determination
Cell Polarization by Rho Proteins