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Updated: Jul 19, 2026

Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
Synchronous ovarian granulosa cell tumor and uterine serous carcinoma: a rare association of a high-risk endometrial
Joseph T Rabban1, Divya Gupta, Charles J Zaloudek
1Department of Pathology, University of California, San Francisco, CA 94143, USA. joseph.rabban@ucsf.edu
Background:
Ovarian granulosa cell tumors are often associated with endometrial hyperplasia or carcinoma. The endometrial carcinoma is thought to occur under the influence of the estrogen receptor pathway and is typically a low-grade, low-stage endometrioid adenocarcinoma.
Case:
We present a case of a woman with a granulosa cell tumor of the ovary and a synchronous serous carcinoma of the endometrium. Immunohistochemical stains for estrogen receptors, progesterone receptors, and p53 protein were performed on both tumors.
Conclusions:
Not all uterine tumors associated with ovarian granulosa cell tumors have low-risk histology. Preoperative evaluation of the uterus with attention to tumor subtyping is important for optimum staging and therapy.
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