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Published on: May 27, 2022
Multi-azole resistance in Aspergillus fumigatus
Susan J Howard1, Ian Webster, Caroline B Moore
1School of Medicine, The University of Manchester, Oxford Road, Manchester M13 9PL, UK. susan.j.howard@manchester.ac.uk
Abstract:
Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole. A novel mutation (G138C) in the target gene (cyp51A) encoding 14alpha-demethylase was detected. The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months.
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