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Updated: Jul 19, 2026

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Published on: August 8, 2017
[Relationship between MC4R gene polymorphyism and body weight trait in beagle dogs]
Yi-Bo Zhang1, Cai-Feng Ba, Yu-Hong Su
1Department of Immunology and Pathogenic Biology, Jinzhou Medical College, Jinzhou 121001, China. jyzyb@yahoo.com.cn
Abstract:
The relationship between MC4R gene polymorphism and body weight in beagle dogs was analyzed. Using gene-specific primers based on canine MC4R exonic sequences a gene fragment was PCR amplified, cloned and sequenced to identify potential polymorphisms. The relationship between a MC4R gene polymorphism detected by PCR-RFLP and canine body weight was analyzed. Three variants were found in beagle dog MC4R DNA sequence, of which two were deletions and one was a transversion which created a PshA I site that could be detected by PCR-RFLP. A statistically significant relationship between this polymorphism and body weight was found. MC4R gene could be a candidate modifier gene for canine body weight.
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