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In search for new antipsoriatic agents: NAD topical composition.

A Wozniacka1, P Szajerski, J Adamus

  • 1Department of Dermatology, Medical University, Lodz, Poland. wozniacka@bmp.net.pl

Skin Pharmacology and Physiology
|October 13, 2006
PubMed
Summary
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Topical nicotinamide adenine dinucleotide (NAD(+)) effectively treats psoriasis symptoms like redness and scaling, comparable to anthralin. For optimal stability, NAD(+) formulations require refrigeration.

Area of Science:

  • Dermatology
  • Biochemistry

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Nicotinamide adenine dinucleotide (NAD(+)) is an adenosine precursor with potential therapeutic applications.
  • The stability of topical NAD(+) formulations is a key consideration for efficacy.

Purpose of the Study:

  • To evaluate the efficacy of topical NAD(+) in treating psoriasis.
  • To determine optimal storage conditions for topical NAD(+) formulations to ensure stability.

Main Methods:

  • A randomized study involving 37 psoriasis patients.
  • Comparison of 1% and 0.3% topical NAD(+) in Vaseline ointment (twice daily) against 0.1% anthralin (overnight) and placebo.
  • Enzymatic method used to assess NAD(+) stability in ointment.
  • Assessment of plaque reduction in erythema, infiltration, and desquamation over 4 weeks.

Related Experiment Videos

Main Results:

  • Topical NAD(+) (1% and 0.3%) demonstrated efficacy comparable to 0.1% anthralin in reducing psoriasis symptoms.
  • NAD(+) showed significant decomposition at room temperature but was stable when stored at 5°C.
  • The NAD(+) formulations were cosmetically acceptable and convenient for twice-daily application.

Conclusions:

  • Topical NAD(+) is an effective and well-tolerated treatment option for psoriasis.
  • Refrigeration is necessary to maintain the stability and efficacy of topical NAD(+) formulations.
  • NAD(+) therapy offers a promising alternative for psoriasis management.