In search for new antipsoriatic agents: NAD topical composition

Area of Science:

• Dermatology
• Biochemistry

Background:

• Psoriasis is a chronic inflammatory skin condition.
• Nicotinamide adenine dinucleotide (NAD(+)) is an adenosine precursor with potential therapeutic applications.
• The stability of topical NAD(+) formulations is a key consideration for efficacy.

Purpose of the Study:

• To evaluate the efficacy of topical NAD(+) in treating psoriasis.
• To determine optimal storage conditions for topical NAD(+) formulations to ensure stability.

Main Methods:

• A randomized study involving 37 psoriasis patients.
• Comparison of 1% and 0.3% topical NAD(+) in Vaseline ointment (twice daily) against 0.1% anthralin (overnight) and placebo.
• Enzymatic method used to assess NAD(+) stability in ointment.
• Assessment of plaque reduction in erythema, infiltration, and desquamation over 4 weeks.

Main Results:

• Topical NAD(+) (1% and 0.3%) demonstrated efficacy comparable to 0.1% anthralin in reducing psoriasis symptoms.
• NAD(+) showed significant decomposition at room temperature but was stable when stored at 5°C.
• The NAD(+) formulations were cosmetically acceptable and convenient for twice-daily application.

Conclusions:

• Topical NAD(+) is an effective and well-tolerated treatment option for psoriasis.
• Refrigeration is necessary to maintain the stability and efficacy of topical NAD(+) formulations.
• NAD(+) therapy offers a promising alternative for psoriasis management.