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Updated: Jul 19, 2026

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
Published on: October 16, 2018
Latent reservoirs for HIV-1
J Blankson1, D Persaud, R F Siliciano
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Abstract:
Combination therapy for HIV-1 infection can reduce viremia to undetectable levels, suggesting that prolonged treatment might eradicate the infection. However, one potential mechanism for viral persistence involves the establishment of a state of latent infection. Recent studies have directly confirmed that HIV-1 establishes a state of latent infection in resting memory CD4(+) T cells in vivo. This reservoir is likely to frustrate current efforts to eradicate the infection with combination therapy.
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