Related Experiment Video
Updated: Feb 7, 2026

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
Localized basal meningeal enhancement in tuberculous meningitis
Salomine Theron1, Savvas Andronikou, Marie Grobbelaar
1Department of Radiology, Tygerberg Hospital, University of Stellenbosch, P.O. BOX 19063, Tygerberg 7505, South Africa.
Background:
Focal basal meningeal enhancement may produce a confusing CT picture in children with suspected tuberculous meningitis (TBM).
Objective:
To demonstrate the incidence, distribution and appearance of localized basal meningeal enhancement in children with TBM.
Materials And Methods:
CT scans of patients with definite (culture proven) and probable (CSF suggestive) TBM were retrospectively evaluated by two observers. Localized basal enhancement was documented as involving: unilateral cistern of the lateral fossa (CLF), unilateral sylvian fissure, unilateral CLF and sylvian fissure in combination, unilateral CLF and sylvian fissure with ipsi- or contralateral ambient cistern and isolated quadrigeminal plate cistern.
Results:
The study included 130 patients with TBM (aged 2 months to 13 years 9 months). Focal basal enhancement was seen in 11 patients (8.5%). The sylvian fissure was involved most commonly, followed by the lateral fossa cistern. The ambient cistern was involved in three patients and the quadrigeminal plate cistern in one. Focal areas of enhancement corresponded to the areas of infarction in every patient.
Conclusion:
Focal basal meningeal enhancement is common (8.5%) in paediatric TBM. This must be kept in mind when evaluating CT scans in children presenting with focal neurological findings, seizures or meningism in communities where TBM is endemic.
More Related Videos
Related Concept Videos
Bioavailability Enhancement: Drug Solubility Enhancement
Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Laminins are the Adhesive Proteins of Basal Lamina
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
Basal Lamina are the Specialized Form of ECM
Proteins...
Type IV Collagen of Basal Lamina
A type IV collagen molecule has six alpha chains which can...
Self-Evaluation: Self-Enhancement and Self-Verification

