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Related Experiment Videos

Fluid-attenuated inversion-recovery SSFP imaging.

Neal K Bangerter1, Brian A Hargreaves, Garry E Gold

  • 1Department of Electrical Engineering, Stanford University, Stanford, California, USA. nealb@mrsrl.stanford.edu

Journal of Magnetic Resonance Imaging : JMRI
|October 13, 2006
PubMed
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A new fluid-attenuated inversion-recovery (FLAIR) steady-state free precession (SSFP) sequence offers fast, fluid-suppressed neuroimaging. This technique significantly improves signal-to-noise ratio (SNR) efficiency for brain imaging, aiding in lesion detection.

Area of Science:

  • Radiology
  • Medical Imaging
  • Neuroimaging

Background:

  • Steady-state free precession (SSFP) sequences are valuable for neuroimaging.
  • Optimizing fluid suppression in SSFP is crucial for enhancing lesion conspicuity.
  • Fast imaging techniques are needed to improve patient throughput and reduce motion artifacts.

Purpose of the Study:

  • To develop and evaluate a novel, fast, fluid-suppressed 2D multislice SSFP neuroimaging sequence.
  • To optimize inversion time (TI) for effective cerebrospinal fluid (CSF) suppression and white matter (WM)/lesion contrast.
  • To assess the signal-to-noise ratio (SNR) efficiency compared to conventional FLAIR fast spin-echo (FSE).

Main Methods:

  • A fluid-attenuated inversion-recovery (FLAIR) SSFP sequence was implemented.

Related Experiment Videos

  • TI was optimized to balance CSF suppression and WM/lesion contrast.
  • Sum-of-squares (SOS) combination of multiple SSFP acquisitions was used to enhance SNR and minimize banding artifacts.
  • The FLAIR SSFP sequence was compared with FLAIR FSE in healthy subjects and a patient with multiple sclerosis.

    • Main Results:

    • The FLAIR SSFP sequence achieved excellent CSF suppression and good gray matter (GM)/WM contrast.
    • Whole-brain coverage was obtained in less than half the scan time of FLAIR FSE with comparable SNR.
    • SNR efficiency was improved by over 50% compared to FLAIR FSE.
    • Clearly visible plaques and excellent brain parenchyma visualization were observed in a multiple sclerosis patient.

    Conclusions:

    • A very fast, fluid-suppressed neuroimaging technique using SSFP is feasible.
    • This novel FLAIR SSFP sequence offers significant advantages in speed and SNR efficiency for neuroimaging.
    • The technique shows promise for improved detection of neurological lesions.